February 2026 SACP/SSP Meeting

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Details for the February SACP/SSP meeting can be found below.

To attend the meeting in person, please register, choose a meal and make your payment by clicking on the green "Register Now" button.

To attend the meeting virtually, please register for a meeting link HERE.

February 2, 2026

Duquesne University - Power Center

5:15 PM Social Hour

6:00 PM Dinner

6:45 PM Business Meeting

7:30 PM Technical Program

Meal Choices

Please choose and pay for only 1 meal selection.

Meat Lasagna with Marinara Sauce
Vegetable Lasagna with White Sauce

Technical Program

“Streamlined Resource-Efficient Plasma Amyloid-Beta Mass Spectrometry Assay Has Improved Biomarker Performance in Preclinical Alzheimer's Disease”

Dr. Thomas K. Karikari, Assistant Professor of Psychiatry and Director of the Biofluid Biomarker Laboratory at the University of Pittsburgh

Abstract: Plasma amyloid-β (Aβ) peptides, alone or in ratio with p-tau217, show strong potential as Alzheimer’s disease biomarkers. While immunoprecipitation-mass spectrometry (IP-MS) is the preferred method for plasma Aβ quantification, current assays are resource- and time-intensive. Here, we developed a streamlined IP-MS method using a cost-effective instrument that significantly improved the efficiency of an original assay by incorporating a single immunoprecipitation step, an optimized buffer system, and approximately 75% reductions in antibody and sample volume requirements. Technical validation revealed excellent dilution linearity (r²>0.99), high precision (<10% variation), enhanced sensitivity, improved Aβ recovery, and markedly increased signal-to-noise ratios. In a large of cognitively normal older adults (n=317), the plasma Aβ1-42/Aβ1-40 ratio achieved stronger concordance with Aβ-PET and superior accuracies to identify abnormal scans (AUC 0.81 vs. 0.65 for the original assay). Notably, accuracies remained high even with plasma volumes as low as 100 μL. The improved IP-MS method enables robust and simplified plasma Aβ assessment in Alzheimer’s disease, with implications for prognosis, diagnosis and intervention trials.

RSVP Deadline: Sunday, January 25, 2026 by midnight

Please note several changes for the 2025-2026 year:

No cash will be accepted at the meeting. All meal payments must be made through this portal using a credit card when you confirm your registration.
The social hour has been pushed back and now starts at 5:15 pm.
Please refer to the new parking procedures that were sent out in an email dated Tuesday, September 2. This information can also be found on the society website.

Thank you.

Want to register a guest for this meeting? Please LOG OUT of your account and use this link:

https://members.chemistryoutreach.org/public/event/details/5567baf8913ae949149514ba61d489a3635b7bcd/1

You MUST use a unique email address for your guest! You CANNOT reuse your email address as the system will then assign the registration to YOU!

February 2026 SACP/SSP Meeting

Monday Feb 02 2026, 5:15 PM - 8:30 PM
Duquesne University - Power Center
600 Forbes Avenue
Pittsburgh, Pennsylvania
United States
15282